Per Carlbring
  • Email
  • Facebook
  • Linkedin
  • Twitter
  • YouTube
  • RSS
  • News
  • Publications
  • MSc thesis
  • Questionnaires
  • CV
  • Contact
Search the site...
  • Swedish
  • English
  • Home
  • Nyheter @en
  • Proof of how the brain changes after cognitive behavior therapy

Proof of how the brain changes after cognitive behavior therapy

Posted on 2015-03-17 by Per Carlbring in Nyheter @en
0

Today we published a new study in the Nature journal called Translational Psychiatry (impact factor 4.360). The paper was about cognitive behavior therapy (CBT) and what happens in the brain after treatment.

It is known that CBT is an effective treatment for social anxiety disorder (SAD), but many patients do not respond sufficiently and a substantial proportion relapse after treatment has ended. Predicting an individual’s long-term clinical response therefore remains an important challenge. This study aimed at assessing neural predictors of long-term treatment outcome in participants with SAD 1 year after completion of Internet-delivered CBT (iCBT). Twenty-six participants diagnosed with SAD underwent iCBT including attention bias modification for a total of 13 weeks. Support vector machines (SVMs), a supervised pattern recognition method allowing predictions at the individual level, were trained to separate long-term treatment responders from nonresponders based on blood oxygen level-dependent (BOLD) responses to self-referential criticism. The Clinical Global Impression-Improvement scale was the main instrument to determine treatment response at the 1-year follow-up. Results showed that the proportion of long-term responders was 52% (12/23). From multivariate BOLD responses in the dorsal anterior cingulate cortex (dACC) together with the amygdala, we were able to predict long-term response rate of iCBT with an accuracy of 92% (confidence interval 95% 73.2–97.6). This activation pattern was, however, not predictive of improvement in the continuous Liebowitz Social Anxiety Scale—Self-report version. Follow-up psychophysiological interaction analyses revealed that lower dACC–amygdala coupling was associated with better long-term treatment response. Thus, BOLD response patterns in the fear-expressing dACC–amygdala regions were highly predictive of long-term treatment outcome of iCBT, and the initial coupling between these regions differentiated long-term responders from nonresponders. The SVM-neuroimaging approach could be of particular clinical value as it allows for accurate prediction of treatment outcome at the level of the individual.

TP_brain

Read the full paper (open access):
Månsson, K. N. T., Frick, A., Boraxbekk, C-J., Marquand, A. F., Williams, S. C. R., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Translational Psychiatry, 5, e530. doi:10.1038/tp.2015.22

Cognitive behavior therapy, fMRI, Just published, social anxiety disorder, social phobia

Subscribe to my Newsletter!

Keep you up-to-date with what is happening. One mail per month.

News

  • The Future of Mental Health Treatment: Prescription Digital Therapeutics, Cyberpsychology, and Care Intelligence Solutions

    2022-04-11
  • Open PhD position in Psychology (with salary!)

    2022-03-09
  • Integrating virtual realities and psychotherapy

    2021-08-03
  • Internet-based cognitive behavior therapy for depression, social anxiety disorder, and panic disorder: Effectiveness and predictors of response in a teaching clinic

    2021-07-14
  • New impact factor for “my” journal

    2021-07-01
  • Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis

    2021-05-04
  • New meta-analysis on genes and psychotherapy outcome in anxiety disorders

    2021-02-25
  • The Prevalence and Clinical and Sociodemographic Factors of Problem Online Gambling: A Systematic Review

    2021-02-02
  • Online Consultations in Mental Healthcare During the Covid-19 Outbreak: An International Survey Study on Uptake and Experiences

    2020-12-17
  • NEW STUDY: How to succeed in keeping your New Year’s resolution

    2020-12-09
  • Virtual Reality exposure therapy for public speaking anxiety in routine care: a single-subject effectiveness trial

    2020-11-30
  • Sudden gains and large intersession improvements in internet-based psychodynamic treatment (IPDT) for depressed adolescents

    2020-11-30
  • Seeking neutral: A Virtual Reality-based person-identity-matching task for attentional bias modification

    2020-11-30
  • Measuring Alliance Toward Embodied Virtual Therapists in the Era of Automated Treatments

    2020-07-09
  • Measuring Alliance Toward Embodied Virtual Therapists in the Era of Automated Treatments

    2020-07-09
  • Internet Interventions for Adults with Anxiety and Mood Disorders: A Narrative Umbrella Review of Recent Meta-Analyses

    2020-05-19
  • In the Absence of Effects: An Individual Patient Data Meta-Analysis of Non-response and Its Predictors in Internet-Based Cognitive Behavior Therapy

    2020-05-18
  • Are physical activity and sedentary behavior related to depression?

    2020-05-13
  • Comparing internet-delivered cognitive therapy and behavior therapy with telephone support for insomnia disorder: a randomized controlled trial

    2020-04-27
  • Deposit Limit Prompt in Online Gambling for Reducing Gambling Intensity: A Randomized Controlled Trial

    2020-04-27

Popular subjects:

Anxiety Attention bias training Cancer CBT Cognitive behavior therapy cognitive flexibility Conference content analysis Depression Effectiveness Exposure therapy fMRI Gambling group therapy ICBT Internet-based treatment Internetbehandling Internet Interventions internet treatment Just published meta-analysis Negative effects Ny artikel Online gambling open access Panic disorder Ph.D. Dissertation PhD Physical activity Problem gambling Procrastination Psychometric PTSD qualitative Randomized controlled trial responsible gambling Review Smartphone @en Social anxiety social anxiety disorder social phobia Stepped care Thesis Treatment Virtual reality
Copyleft (ɔ) 2020 Professor Per Carlbring